Harmon led the series as Boston homicide detective Jane Rizzoli after earlier regular roles on Baywatch Nights and Law & Order.

She later starred in and produced the television-movie series Buried in Barstow. Her voice work has also included Commissioner Barbara Gordon in animated Batman productions.

Alexander played chief medical examiner Maura Isles, pairing scientific precision with Jane's investigative instincts. Before the series she portrayed Caitlin Todd on NCIS.

Later work included Shameless, Dangerous Lies, and directing episodes of You and other television series, extending her career behind the camera.

Bracco portrayed Jane's energetic mother Angela Rizzoli. Her earlier film performance in Goodfellas earned an Oscar nomination, while psychiatrist Jennifer Melfi on The Sopranos brought multiple Emmy nominations.

She later appeared on Blue Bloods and in the film The Birthday Cake.

McGill played veteran detective Vince Korsak, Jane's former partner and trusted mentor. His long character-actor career includes Animal House, MacGyver, My Cousin Vinny, The Insider, and Lincoln.

Later television credits include Reacher and Love & Death, continuing a five-decade screen résumé.

Young portrayed detective Barry Frost during the first four seasons. He first became widely known through Disney Channel's The Famous Jett Jackson and later appeared on Friday Night Lights and Scrubs.

Young died in 2013; the series subsequently acknowledged Frost's death, and this entry respects a completed career.

Bridges played Jane's brother Frankie, who develops from patrol officer into detective. Earlier credits included Mona Lisa Smile and Conviction.

After the series he appeared in Gone, Christmas at Holly Lodge, and other television films, maintaining a career across procedural drama and lighter features.

Victor joined as crime analyst Nina Holiday and became a series regular for the final seasons.

Her other television work includes Turn: Washington's Spies, Shameless, Love Is__, and Minx. Those roles span period drama, contemporary comedy, and technology-focused procedural work.

Goodman recurred as Lieutenant Sean Cavanaugh, the detectives' commanding officer. As an actor he has appeared in Catch Me If You Can, Munich, and The Last Castle.

He also co-wrote and directed What Doesn't Kill You and directed episodes across network and streaming television.

Huang portrayed senior criminalist Susie Chang, whose laboratory work supports the investigations.

She later took daytime roles on Days of Our Lives and General Hospital and appeared in Queen Sugar. Her credits also include stage performance and guest work across comedy and drama.

Egglesfield recurred as Jane and Frankie's younger brother Tommy Rizzoli, whose choices complicate family life.

He previously played Josh Madden on All My Children and later appeared in Something Borrowed, The Client List, and Chicago Fire. His career combines daytime, film, and prime-time roles.

Sinclair joined the later seasons as assistant medical examiner Kent Drake, bringing a different energy to Maura's workplace.

His earlier credits include the British drama Mile High and the science-fiction series Painkiller Jane. He has continued acting in television and independent film projects.

Burke appeared as FBI agent Gabriel Dean, a complicated figure in Jane's personal and professional world.

He is also known as Charlie Swan in the Twilight films, led the series Revolution, and later joined Fire Country as Vince Leone. Music remains another public part of his creative career.

Wahlberg guest-starred as Lieutenant Joe Grant, Jane's former colleague.

His acting career includes The Sixth Sense, Band of Brothers, the Saw films, and a long run as Danny Reagan on Blue Bloods. He also continues performing with New Kids on the Block.

Bisset recurred as Maura's adoptive mother, artist Constance Isles. Her international film career includes Bullitt, Day for Night, Murder on the Orient Express, and Under the Volcano.

She won a Golden Globe for the miniseries Dancing on the Edge and has continued screen work into the 2020s.

Lawrence played Hope Martin, Maura's biological mother and a physician. Her earlier work as Sylvia Costas on NYPD Blue brought multiple Emmy nominations.

Later credits include Queen Sugar, Shameless, Joe Pickett, and stage productions, reflecting a sustained career in ensemble drama.